I've written a few times about starting to unbundle and move on from certain parts of Blueprint (post here about Longevity Mix and Essential Capsules, and my comment here about the Essential Softgels). People have asked me to write out the full details, which are below.

First, let me say that I love Blueprint and what Bryan is doing. He's testing on himself, and publishing the info, and helping thousands of people in the process. I've also happily spent thousands of dollars on his supplements over the months. I proudly own and tote around a Blueprint shaker! Even after moving away from these all-in-one supplements, I still intend on buying the Snake Oil olive oil (drizzled on lunch and dinner) and the Cocoa Powder (scoop in morning coffee with collagen), and will await new products and emails from him eagerly.

Secondly, I eat really healthily and so while I might get certain nutrients from my diet, it doesn't mean you will. Just like how these supplements helped get me here, they might be most useful for people just starting out in their health journey. For quick reference, my diet typically is: 1/ Breakfast: greek yogurt, nuts and berries, protein shake. 2/ Lunch: green leafy salad with cruciferous veg, avocado, lean meat or fish, sauerkraut, olive oil and apple cider vinegar. 3/ Dinner: lean meat and roasted or steamed veg with olive oil. I rarely eat out, snack or drink alcohol, and so would be 90% adherence to this.

Thirdly, I think Bryan has a really poor set of doctors around him. Don't forget, someone told him to (or at least oversaw him) consume red wine with breakfast daily...for longevity. I disagree with his stances on: daily antioxidants (they blunt gains from exercise, so I only take them on off days, Vitamin E builds up over time and can shorten lifespan), daily Metformin (blunts exercise gains, I take it when on vacation/off weeks only), Rapamycin (maybe it increases heart rate and blood glucose, but so do exercise...which no one suggests stopping) and others.

With that, details below. Hope it helps some of you make your own informed decisions.

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Longevity Mix
(Blueprint link here)

Contains:
Vitamin C
Magnesium
Creatine
Glucosamine Sulfate
Taurine
Glycine
L-Lysine
Ashwagandha
Glutathione
L-Theanine
Sodium Hyaluronic Acid

What I'm replacing these with:

• Shield by Renue contains Vitamin C, CaAKG, Sodium Hyaluronic Acid in a superior liposomal format. More Vitamin C, a bit less Hyaluronic Acid, a lot less CaAKG (but its lipo) and it has some PEA too (not important to me): Cost $0.52 per day
• For the Amino Acids/Peptides: Creatine ($0.16 to replace the 2.5g), Taurine ($0.03), Glycine ($0.03) I take these in higher doses already via either powders (Bulk Supplements, these are the prices I quoted) or increasingly via 1g capsules (Nutricost, who have a 40% black friday sale on right now). I take enough protein from foods and shakes that I don't need to supplement with Lysine separately.
• Magnesium: Nature's Bounty Magnesium Glycinate which are $0.07 per 120mg from Costco
• Glucosamine Sulfate: Costco's Glucosamine and Chondroitin $0.08
• Ashwagandha and Theanine: I try to avoid herbal supplements due to contaminants, heavy metals, uncertain dosing, side effects and so on. I especially do not want Ashwagandha in the morning, due to its lowering effects on cortisol, which you want high in the morning. I also drink Green Tea most days. I don't supplement with these two.
  
• Glutathione is poorly absorbed orally, and so I focus on the NAC precursor only.
  

Total Cost: $0.97 vs $1.55 per day
You could probably find ways to add back in all the things I've skipped for the saved $0.70.

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Essential Capsules
(Blueprint link here)

Contains:
Vitamin D
Vitamin E
Vitamin B1 (Thiamine)
Vitamin B2 (Riboflavin)
Vitamin B3 (Niacin)
Vitamin B5 (Pantothenic Acid)
Vitamin B6 (Pyridoxine)
Vitamin B7 (Biotin)
Vitamin B9 (Folate)
Vitamin B12 (Cobalamin)
Calcium
Iodine
Zinc
Selenium
Manganese
Nicotinamide riboside 
Broccoli Seed Extract
Fisetin
Luteolin
CoQ10
Probiotics
Spermidine
Boron
Lithium

What I'm replacing these with:

• Vitamin D: Costco 2,000 IU. $0.02 per day for the same dose (I take more)
• Vitamin E: I do not think people should supplement with a fat soluble antioxidant like Vitamin E, the data shows excess amounts can shorten lifespan. I use Cronomoter occasionally to track my foods, and I get enough from diet (Vit E is high in olive oil, leafy veg, nuts, eggs etc).
• Vitamin B Complex: I will take half a dose (1 capsule per day) of Life Extensions B Complex. On Amazon that's $0.07 per day.
• Calcium: Medical advice is that people should not supplement with extra Calcium, due to calcium buildup in the arteries. I get enough Calcium from (grass fed) dairy.
• Iodine: I get enough in my diet (seafood and dairy)
• Zinc: I take quite a lot, and am tested regularly to ensure I'm in range. Nutricost (0.5 capsules per day). About $0.02 to cover the dose in the capsules.
• Selenium/Manganese: Careful you aren't getting too much already... 6oz of chicken and 1 egg is already the day's RDA for Selenium, and 2oz of nuts can contain the day's RDA of Manganese. When I've tested my blood for metals, I was high in both of these, so I'm happy to remove excess supplements from my diet.
• Nicotinamide Riboside: I've tested my blood NAD levels twice, and in normal ranges I don't seem to need supplementation. Recent research by David Sinclair (sigh) implies massive doses (3g of NMN) may be needed to see effects - and that's from one of the main NAD proponents. To cover my bases I take 50mg of Niacin (Cost $0.06), which gram for gram raises blood NAD levels more effectively than either NR or NMN.
• Broccoli Seed Extract: This one really frustrated me...the Blueprint supplement contains Glucoraphanin but without the Myrosinase enzyme its only on average 5% bioavailable. So I upgraded to one of the best supplements in this category, by Avmacol. Cost: $0.68, but only on off days...because, wait for the kicker, Sulforaphane itself is anti-androgenic! Again, <3 Bryan, but he needs to fire his doctors and advisors...as thousands of people are trying to achieve gains, and yet blindly blunting their success daily.
• Fisetin: Another doozy. I don't think people under 60 should accidentally take senolytics, especially not daily. Cell senescence is an important part of tissue regeneration, and it's only when senescence runs out of control when you get older that managing this via occasional use of senolytics makes sense.
• Luteolin: Luteolin and Rutin supplement by Horbaach. Rutin is a nice thing to add...its a polyphenol. $0.19 each (again, off days only...due to the blunting effects on exercise).
• CoQ10: Good that it's the active/reduced form and not yet another anti-oxidant. I take a higher dose from Swanson. You could match the dose, at 0.5 softgels per day for $0.18.
• Probiotics: Not needed for me, I eat lots of fermented foods daily (yogurt, sauerkraut, kombucha etc).
• Spermidine: It has very poor oral bioavailability, so I get it from foods. It's in mushrooms, legumes, whole grains, aged cheese - which I also consume for the C15 benefits!
• Boron: Life Extension Boron. I take 6mg per day as I try to unbind my testosterone a bit more. Cost $0.05 for 3mg.
• Lithium: I don't think it would benefit me, but its only $0.10 to replace the 1mg via Life Extension if you want to.

Total Cost: $0.87 vs $1.55 per day
Depending on your stance on daily antioxidants, NAD precursors, lithium and your diet, you may not be able to replace this stack 1:1 at the same cost or lower.

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Essential Softgels
(Blueprint link here)

K1
K2 MK4
K2 MK7
Astaxanthin
Lutein
Lycopene
Zeaxanthin

• K Complex: Life Extension Super K for $0.20 each, has each of the 3 active forms. Same dose of K1, lower doses of the two K2 forms, but that’s fine for me.
• Astaxanthin: Sports Research. $0.33 each, same dose as Blueprint, but as a superior branded ingredient.
• Lutein / Zeaxanthin: Sports Research $0.16 each. More of each ingredient, and in a superior branded format.
• Lycopene: I'll just eat tomatoes occasionally.

Total Cost: $0.69 vs $1.55 per day
Pretty sure you can buy a small tomato for $0.76 per day

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Overall this saves me around $775/year, and gives me more control over what, and in what dose, I'm consuming. It's more work to manage, and requires I maintain my healthy diet, so YMMV if you try to copy this - which I don't recommend. Instead, I wrote this up as a resource, allowing you to pick and choose the things that make the most sense for you, given your unique needs and wants.