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Is THC-O-ACETATE really five times stronger than delta-8?
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I've seen the following claims repeated ad nauseam anywhere the topic of THC analogs comes up: THC-O is three times more potent than delta-9. THC-O is five times more potent than delta-8. THCP is 30 times more potent than delta-9.

I'll admit, I never took too close a look at the first two claims, seeming plausible on the surface. I just guessed that the acetate ion could bind to more than one THC, thus liberating more when the liver breaks it down. Now I'm writing a report on the current market for THC analogs and the more times I hear this claim without a usable citation the more I'm beginning to think it's just some silly urban legend or marketing stunt. The more I think about it, the stupider I feel for my previous idea as I imagine 30 THC molecules bound to one phosphate ion.

Can anyone verify any of these claims with a credible source? What does "more potent" even mean in this context? Longer duration? More intense stimulation of the neurons? Or is it really some clown car prodrug that just some how breaks down into more THC than appears possible?

Any help would be more than greatly appreciated, it'd be life saving because if I have to click "Next Page" on Google Scholar again, my head is going through the monitor.

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1 year ago