I'm on day 9 of switching to Trintellix from a combo of Buspar and Lexapro and these side effects are no joke. I'm constantly nauseous and itching like crazy, and irritability comes and goes like a wave. I've also been randomly crying for the past 2 days for absolutely no reason at all. And man, the headaches! I've taken an extra strength Tylenol every day for the last 5 days and it's barely even touching the headaches. All I'm getting are side effects - I feel absolutely NO better and if anything, worse. At least on the Lexapro and Buspar I wasn't randomly crying for no reason. I'm trying to hard to stick it out at least 30 days, but if I don't start seeing SOME kind of benefits soon I may have to come off Trintellix. This is the worst medication I have ever taken.