Hey r/trans,

Baby trans / enby (transfem) here. I just agreed to start a HRT regiment after a few visits with different endocrinologists and finding one I’m most comfortable with.

I told her I wanted whatever “feminizing” benefits I could obtain while avoiding breast development, phallic atrophy and infertility.

We discussed many options including: * Raloxifein SERMs * Bicalutamide * GnRH agonist/antagonist SERM or low-dose estradiol * High-dose bicalutamide SERM * High-dose progestogen (e.g., low-dose cyproterone acetate) androgen receptor antagonist (e.g., bicalutamide or spironolactone * Low-dose oestrogen topical cream

We finally, based on her professional advice, came to the conclusion that those options carried unwanted risks (I.e. blood clots) or unwanted side effects (atrophy, breast development, high risk of infertility).

She recommended I try a transdermal low-dose estradiol patch. She didn’t state the dosage (TBA) but I know the lowest dose is 0.025mg and I’m assuming that’s what we’ll go with.

Does anyone have any experience utilizing this as their only HRT regiment, with no other forms of hormone replacement or hormone blockers? (I do take dutasteride and minoxidil to block DHT)

Just want others anecdotal experiences or their best “Reddit professional” opinions on this, bearing in mind all experiences are individual.

Thank you so much!