I'm refering to that interview with Thierry Boulanger, the creative director.

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• Trophies aim to be "meaningful", to highlight impactful moments and challenges
• Approximately half the trophies are earned naturally by progressing through the main story.
• The other half involves skill-based tasks, completion, exploration, and optional challenges.
• Changing the difficulty with the relics (e.g. double HP) doesn't lock you out of trophies
• There is an ingame tool to track your trophies
• No missables(!) but the hardest trophy requires an (almost) full NG playthrough
• This hardest trophy is to beat 10 bosses with a relic equipped that makes enemies one-shot you and you need perfect block timing to reduce the damage(very minor spoiler)

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Looks like a very nice trophy list, I'm SO hyped for this. GotY? :D