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I want to write a story about Adam and Eve from a more advanced alien sci-fi perspective. So, the question is, assuming that these two people were genetically created from the ground up to not have any genetic diseases anywhere in their DNA alleles, would that solve the problem of birth defects?
Edit: I have been criticized for using the term flawless genes. I apologize, I should have used the term non-diseased or something else. I was not intending to sound like a eugenicist. The question is purely about whether two humans could create a global population.
Do you mean "a couple of people" or "a couple"?
Because there's been extensive studies about genetic bottlenecks both past (the story of the flood we see over and over again may derive few hundred early humans being all that was left before they bred themselves back to full strength) and theoretical and it seems the numbers aren't that low.
Just two? Maybe. Possibly. Thing is genetic flaws naturally accumulate so you'd have to very much reintroduce a minimum level of genetic distance after a while.
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Don't over explain it or you'll have to explain why they aren't immortal.