Now I know the whole the alien non-interference clause aka the prime directive was created to prevent other races from interfering in another's social, technological, and cultural development. But personally I think a policy of complete non-interventionism is pretty immoral. Take the Rwandan Genocide as an example. Over 500,000 people were murdered by a fanatical regime and, forgive me for saying this but, I feel like the West's inaction over this makes them partly responsible. Furthermore some like Isaac Arthur argue that if such a policy was implemented it would be disastrous because there will always be a few individuals that will act against it and once the primitive aliens obtain interstellar flight they will be pretty peeved at us for just standing by and observing while they suffered through numerous wars, famines, disasters, and genocides.

In any cases what are the best works of science fiction that deconstruct, avert, or defies the alien non-interference clause?

So far the best ones that I know of are Player of Games by Iain Banks, Three Worlds Collide, Stargate SG-1, Uplift by David Brin, and Hard to be a God by the Strugatsky Brothers.