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8
Using RC’s to replicate the cocaine experience
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So my theory is that by combining

moderate dose of a phenidate

Low dose 3-ho-pcp or 3-meo-pcp

Micro dose MET or 4-ho-met or 25b-nboh

could be what the borax combo is for mdma, a comparable experience made from multiple agents

In general cocaine acts as serotonin:dopamine reuptake inhibitor with a ratio of 2:3. As a sigma agonist, nmda antagonist and low affinity agonist of 5ht2a 2c and 2b receptors

3-ho-pcp and/or 3-meo-pcp immediately reminded me of cocaine with their nmda antagonism (ki 20nM), serotonin reuptake (216 nM) and sigma activity

Looking for advice on the ratios of each or experiences in the area

Additions

If serotonin reuptake needs to be amplified then venlafaxine would be my top pick

If sigma activity was low PPAP is rather selective in this action

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