Another 2-BM trip report by not myself, but my anonymous friend going by “TheOperator”.

TheOperator’s voice:

45 mg trial: In my previous report on the 45 mg trial, kindly published by my friend u/tar_and_product on reddit, I forgot to document some after effects I experienced: The sleeping period directly following the psychedelic experience was uninterrupted and lasted 10 h. During the next day, I noticed considerable anorexia induced during the trial on the previous day. Moreover, I noticed an increased sensitivity to cigarettes, caffeine and melatonin. On the evening of T 1 day I attempted to induce sleep with 0.5-1.0 mg of melatonin (oral administration), but instead of tiredness it precipitated euphoria, increased music appreciation and an intensification of colour perception. I didn’t sleep during this night and stayed awake for almost 40 h without any negative physical or psychological side effects. My creativity and productivity stayed enhanced and my mood elevated for several days. I speculated that this compound could be a useful anti-depressive medication.

However, a singular trial is insufficient to characterise a compound fully as set and setting contain too many unknown variables. Thus, I repeated the trial with a 33% increase in dosage. This should reveal the full effect spectrum of 2-BM and, to the best of my knowledge, presents the highest-in-human trial of authentic material to date.

Subject: Weight (50 kg), Height (180 cm), Age (26 years). Previous experiences with 45 psychoactive substances including > 100 experiences with 17 psychedelics/their prodrugs (LSD, 1P-LSD, LSA, Psilocybin, 4-AcO-DMT, DMT, DET, 5-MeO-MiPT, Mescaline,2-BM, 3,4,5-TMA, 2C-N, 2C-D, 2C-E, 2C-C, 2C-B, 2C-I). Hypertension and adverse cardiac events absent >= 1 month before exposure. Respiratory infections absent >= 5 days before exposure. Administration of psychedelics from the 2C family on a weekly basis for over 2 years as a self-medication of depression, which was found superior to standard clinical therapy. Before and after echocardiogram showed no structural changes in the heart and valves; before and after ultra-high-resolution cranial MRI showed no change in brain volume.

ROA , Dosage, Identity of the Material: Oral administration (gel capsule), 60 mg of the hydrochloride salt of 2-Bromo-3,4,5-trimethoxy phenylethylamine (pure compound) on an empty stomach.

Set and Setting: Private apartment and surroundings. Noon to early morning, warm (30 °C) summer day. Well rested (9 h of sleep), administration of 2BM 3 h after awakening. Potassium ascorbate (500 mg), magnesium citrate (350 mg) and ibuprofen (300 mg) at T – 01:00 h. Resting BP 107/79 mmHg , HR 69 1/min, pO2 99%. A trip sitter was assisting during the first half of the experience. A hospital with highest-standard-of-care ICU capability was in very close reach at all times.

Cross-Tolerance: 5-MeO-MiPT HCl (5.0 mg) at T-15 days, 2-BM HCl (45 mg) at T-7.5 days: Tolerance to psychedelics should be at or near baseline.

Timeline:

Induction and come up:

T 00:25 First alerts, which rapidly escalate into an unpleasant body load and profound mental alteration. This dosage means business.

T 00:45 The rapid onset is unexpected and overwhelms me. I lied down on my bed, attempting to stabilize my physical and mental situation. Physically, there is a tremendous body load with muscle rigidity, slight shivering and nausea. I frequently crawl to the bathroom and attempt to vomit, but to

no avail as my stomach is perfectly empty. Mentally, I’m quite nervous and concerned as this response is unexpected. The peak is expected at 1:30 h, where is this going to go??

T 01:00 Peak is already achieved. Mentally I’m in a dark place. My companion starts conversation, apparently he doesn’t realise that I’m severly affected. We converse about the mescaline derivative human trials. As he remarks on possible dangers and complications, I panic somewhat. In my mind, I play out all possible scenarios: herg channel? Thyroid? Serotonin syndrome? It aggravates me that he brings this up just as I’m ACTUALLY HAVING SIDE EFFECTS FROM AN UNKNOWN COMPOUND! I request for him to change the topic. The pauses between my spoken words become longer and my sentences shorter, until I only respond with yes/no answers. I’m feeling mentally debilitated. He suggests to leave the room and head for the forest, but I refuse repeatedly due to my fragile state. An attempt to stand up is met with some dizziness. I experience walking difficulties, taking on a hunched, forward-leaning posture. Finally, we evacuate my room and walk outside.

Peak:

T 01:00 to 04:00

In order to reach the forest, we have to walk roughly 1 km through open terrain. The temperature outside is at about 30 °C and the sun is burning mercilessly. I’m mentally switching back and forth between two extremes: On one hand, I feel weak, over-heated and there are worries for passing out from heatstroke. On the other hand, stimulation and euphoria are rising and there is a sense of invulnerability. If I wanted I could ignore my body. But should I? I check my heart rate, which is at 80- 90 1/min. No tachycardia, we are still in the clear. The nausea is slowly receding. Visually, I notice strong halos around bright objects, but colours and textured surface remain unchanged. I listen to music in order to steer the experience into a friendly direction: D&SCO set from twomanydjs/RadioSoulwax, as well as experimental electronic music from the 70s (Cybotron). The music appreciation is significant and a sizable euphoria is manifesting. Talking becomes easier as we make our way through the pine forrest and I get to distract myself from the body load by exploring the wilderness. We encounter some mushrooms, both edible and fatally poisonous. I collect the edible ones, still confident in my judgment (It later turned out that all mushroom identifications made during the trip were, indeed, correct). Tactile sensations are similar to the 45 mg trial, but more complex. I noticed that the sensations of touch, tingling, pain and temperature are mixed up. Moving my fingers induces a rainbow of perceptions: cold, then heat, then as if my fingers are wet and finally stinging electric pain. It’s like a synaesthesia, but limited to the skin. At the 02:30 h mark, we leave the forest and settle down on some benches near the neuro-biology campus. My companion offers me food and I accept gladly. Contrary to the last experience, my appetite is normal. I eat a banana, which improves my nausea and physical discomfort. We engage in a long discussion about miscellaneous topics as we continue the walk towards the institute of pathology.

Comedown:

T 04:00 Effects begin to slowly subside, yielding a peak duration of about 3.0-3.5 h. As my nervousness and physical discomfort dissipate I decide on a cigarette. We ended up chain-smoking an entire pack of cigarettes over the next 1-1.5 h. Indeed, the nicotine craving is as strong as previously reported.

T 10:00 Most of the psychedelia has disappeared. I walked around the university campus and inspected some plants before attempting to do some work. This, however, was futile as I couldn’t keep up my concentration.

T 14:00-16:00 Mostly back to baseline. Some trailing mood elevation. Sleep (10 h, uninterrupted) was achieved at 16:30 h. Over the next days, mood elevation was maintained. Roughly 2.5 days after dosing, I noticed a mildly psychedelic state of mind and increased response to caffeine and cigarettes. There were halos around light sources, music sounded deeper and profound, euphoria manifest. I refer to this as a psychedelic recurrence, which seems to be a consistent feature of 2-BM for me.

Effect Analysis and Commentary:

I will compare this experience to the previous trial.

(1) Temporal effect evolution The onset was significantly shorter. This dose hit hard and early. The overall duration was moderately increased to about 14-16 h total. This brings it almost into the 18-20 h range of mescaline itself, though most of it stems from the slow offset. This is along one!

(2) Efficacy The effect spectrum was essentially identical to the 45 mg, which implies that the efficacy is low and rapidly converging. So, a further dose escalation is unlikely to reveal additional features and is discouraged. There are no proper visuals, its mostly headspace, touch and hearing. The headspace is moderately clear, though that’s difficult to separate from the negative body load.

(3) Dose response curve The dose response curve is strongly non-linear. Above ~ 50 mg, a dramatic increase in effect strength is noted. I might consider 65-70 mg at a later time to confirm, but not right now. This one is not a winner I’m afraid. Persons naïve to the material should do their own titration from about 40 mg upwards in 10 mg steps. Perhaps this is one of those compounds with a broad variability in susceptibility.

(4) Side effects Generally, the cardiotoxicity appears to be low to moderate. However, there is a significant body load in the high-dose regime. In the comment section of my last report there was some talk about a lower body load in the halo-mescalines. This turned out to be false. I would compare the side effects of 2-BM equal in strength and symptoms to 300-350 mg of mescaline, and I would always prefer the latter. (Mescaline is, along with DMT, my all time favourite psychoactive substance, so this is not a surprise...)

(5) Anorexia and the 2-phase-splitting of the peak are either inconsistent features or unique to the low-dose regime.

(6) After effects This compound reliably produces long-lasting anti-depressant effects and psychedelic recurrences. I speculate that is might be a valuable medication. If the patient requires only 2 applications per week, the side-effects and drug-drug interactions would be significantly reduced compared to standard treatment. This requires further investigation in a proper clinical trial, a promising compound! The psychedelic recurrence might be linked to MAOI activity. Having been able to witness the full effect spectrum of 2-BM, I feel confident to rank it on my Jacob’s ladder of psychedelics: It’s certainly above 2C-N, 2C-C, and 5-MeO-MiPT; about equal to DET (but no substitute!); perhaps slightly inferior to 2C-D. Not good not horrible.

Result:

60 mg affords a strong low-efficacy experience with onset 20-40 min, peak 3-4 h min, total duration 10-16 h. The cardiovascular safety profile is favourable, other side effects such as nausea and diarrhea are discouraging for recreational usage. 2-BM is probably best suited as a medication for the clinically depressed in the lower dosage regime, with low potential for abuse.