This is entirely new and I was enjoying the game happily until this happened.

Basically when I try to put the game into 1080p (My native resolution) the game will do 1 of 2 things. It will either automatically display at 768p or it will display at 1080p but shrink the entire UI to the left side of the screen. I would try using a reduced UI but I cannot because everything is out of alignment. i.e. the game registers my cursor 2-3 inches to the left of where I actually see it. Things on the right side of the screen are completely unselectable. Because in order to click on something like the settings button in the top right, my cursor would need to be 2-3inches outside of where my screen ends.

I would run with maximized windows instead but I get massive framerate hitching when I do. Which basically renders a MOBA unplayable. It's sort of infuriating when a team fight breaks out and you have to wait 5 seconds just for 1 new frame to render

Here is a video of my problem: https://youtu.be/DBXIH-yrd6c

Edit: System Specs i7-3770k/ GTX 760 2GB/ 8GB Ram/ 2x 1080p samsung LED monitors (22 & 32 inch)/

Edit: Thanks to PARAGON_e I think I have a solution. Custom Resolution Utility seems to fix the issue. Haven't had the chance to play a game yet as final test but everything is fine so far. Thanks for the help guys, you rock