Not sure if this is most appropriately asked here or at r/drugs, but the community here seems very insightful and helpful, so thought I would share here.

To ask briefly, I'd love to know if anyone else experiences crippling nausea on the comedown of high dose insufflated ketamine? I'm referring to doses above 100-150mg with very minimal tolerance. And has anyone found a way to reduce the nausea post experience?

Some context is probably helpful, so I'd like to share my two high dose experiences, in case it's of interest to anyone.

First High Dose Ketamine Experience (estimated 150-200mg insufflated, on the tail end of 120mg MDMA orally)

Very early on in my exploration into ketamine (3-6 months infrequent experience), I accidentally took a far higher dose than intended and put myself into a K-Hole. At the time I was learning the drug in social and party settings, at very low doses and getting familiar with it.

I was visiting friends in Barcelona and we were enjoying San Juan festivities, think street parties, celebrations, beach fireworks ext. My friends and I were enjoying MDMA throughout the night and around 2am, I asked one friend if he would like to share a line of ketamine together.

At the time our friend group was doing this stupid habit of making one long line and people would just take from that what they wanted, rather than even divides. So I made one fairly long line on the phone, probably the length of my middle finger and fairly thick. It was dark and I was a little high, so stupid things were done. Unknowingly, my friend took a very small portion from the end. I thought he took half so proceeded to snort the rest.

I was sitting talking to someone in the group, when, a minute or two after snorting it, it felt like gravity had tilted and was pulling me backwards towards the beach we were sitting on. I remember I had just enough time to explain to the person next to me that I took a high dose of ketamine, and not to panic while I lie down for a bit.

I remember lying back onto the sand and closing my eyes, and having this feeling that I feel through the sand and into a black abyss. Visually at first there wasn't much, just blackness, though my thoughts and perception of consciousness was still there, my inner monologue was still very much active. I remember trying to open my eyes or lift an arm, and starting to panic when I couldn't do either, and panicking more when I felt that I no longer had arms, legs, or a body. I was just a thought and a floating consciousness, it was very strange.

At the same time, visuals started to appear. It wasn't anything spectacular, best description is a yellowish tunnel that I was now floating and moving through. This was a little calming but my panic stayed as I couldn't get out of it, couldn't open my eyes or escape. I started to gain this thought that I had overdosed on ketamine and this was, perhaps, death. I thought that I had died and this was what happens after. For some reason this was the most logical conclusion from a lack of understanding of ketamine as a drug, and not being able to connect with my body or get out of the experience.

I was stuck in this state, floating in a tunnel, reflecting on my actions that had caused me to end my life, for what felt like hours, I felt over that time that I had to let go and find peace with the situation, and what I believed I had done. Eventually little bits of reality and the environment around me began to creep into my experience. I could hear the sound of my friends talking around me, and I had some familiar stimuli that pulled me back to reality. I remember trying to talk at first, and just hearing blurred sounds coming out of my mouth. The relief that I was alive, and had survived the experience felt amazing. But at the same time I was extremely overwhelmed. Apparently I was unconscious and unresponsive for a good 90 minutes. Luckily some people in the group had experience with this kind of situation and knew what to do.

The nausea that followed was the worst I have ever experienced in my life. Coming out of the K-Hole, I spent the next 15 minutes in a fetal position vomiting and dry retching. Somehow we made it back to the apartment and I took a good 12-24 hours for the nausea to pass and to get enough strength back to walk around and function again.

Second experience (180mg snorted):

After my previous experience, I gave ketamine a lot of respect, and made sure to avoid any high dose situations. It scared me out of wanting to relive that experience. But a little bit of me was always curious to how it would be to revisit, in a better set and setting, a better understanding of the compound, and no other drug interactions in my system.

So, 5 years later, I decided to try a high dose experience again. This time I was at home, in a comfortable space with my partner trip sitting me. I had a good nights sleep and went into it completely sober. I snorted a weighed 160mg, and proceeded to have a less intensive, far more relaxing experience. It was no where near as scary as the first.

Unfortunately, coming out of the experience, I had the same crippling nausea, non stop vomiting and weakness that took me 12-24 hours to recover from.