TL;DR at the bottom

I’ve recently cut out the ibuprofen & just started taking diphenhydramine alone. I need the pain relief but I have severe anemia & have thought maybe the ibu could be causing blood loss (don’t have any ulcer symptoms but I haven’t started dx’g yet)

I’ve felt strange ever since. But Monday, I also had a bad reaction to a mmj edible (was “locked in” for almost 3 hours, I thought I was having a stroke). Could the diphenhydramine be metabolizing differently alone than the combo?

I have a host of other medical problems I should be having diagnosed but not really interested in doing anything to prolong my existence (therapy is on the to do list as well)

But I’ve never taken Benadryl just for allergies, always as a sleep aid & with a painkiller like ibuprofen or acetaminophen. I stopped the acetaminophen because of the potential for liver damage after long term use. I’ve had sleep problems since around 1995 & they just get worse with age. If I try to sleep with nothing, I just doze in this really disturbing limbo. Very similar to what I experienced Monday but I literally do not even remember “trying “ to go to sleep, which makes me think it was the edible. I was thinking coherently, the day was just on replay in my head, but I couldn’t move without a LOT of effort. Even swallowing was deliberate, not reflexive.

My apologies for this muddled mess. Essentially the question is can diphenhydramine alone cause a different reaction than when combined with a painkiller?