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How to Upregulate a1 GABA Antagonist/ Receptors (and NMDA) - Benzo Tolerance?
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I have included the relevant information of my subject and question to my post up here (below) for those who donā€™t desire to read my entire lengthy post; which could and would be relevant to your reply anyway. Nonetheless hopefully something comes out of thisā€¦, This is my first real ā€˜sincereā€™ post; here we go. Nervous its going to be ignored.
Subject of question: Being able to take my prescribed daily dose of klonopin and Xanax preventing tolerance and withdraws or at least to some degree by interfering/interacting with my GABA and NMDA antagonist/receptors.
How may I accomplish this?
If you have any other methods accomplishing my goal, what may those be? I am open minded.
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Please read, Iā€™ve put a lot time into this; itā€™s long but i think its relevant but no pressure. Itā€™s not straight to the point (sorry), Iā€™m just seeking genuine help due to health problems that have been going on since high school - going on 10 years now, anything that you may have to offer that could improve my standard life of living would be greatly appreciated. Sorry for my format, grammar and punctuation being off or incorrect, iā€™m just trying to make it an easier read with how Iā€™ve written this.
OK I HOPE YOUR STILL WITH ME!
I have a multitude debilitating systemic health issues at my young age currently; i am very healthy - well in other regards - explained later. My health issues mostly consisting of, respiratory issues, MAJOR CHRONIC sinus issues with two major surgeries (effects sleep like you wouldnā€™t believe), digestive issues (severe - plenty of natural fiber- Metamucil can only remotely help - can go days with no bowel movement making me feel more sick), sleep and insomnia, server anxiety and panic with agoraphobia (worsened as my health diminished), major concussions (2 very severe) with no proper care or treatment following, severe memory issues, autoimmune; and much more - honestly only maybe a few lol. Iā€™ve tried many avenues of treatment and have been open minded. Iā€™m fairly young and honestly sick of it; no pun intended. Iā€™ve seen way to many doctors for my ageā€¦
I have seen plenty of doctors in and out of state whom been ā€œhighly regardedā€ and the standard referrals but always ends up inconclusive despite abnormal findingsā€¦ Or them pushing a specific drug i declined for valid reasons. Iā€™ve had the run around for years; imo. I went to UPMC for treatment once and my ā€˜doctorā€™ wouldnā€™t consider treating me unless i got the covid vax; also very rude and ā€˜spoke down to meā€™. With autoimmune problemsā€¦ I am not taking something SO experimental and man am i glad i ā€˜carryā€™ this ā€˜mindset and knowledgeā€™ (opinion) i have about the current state of our world; horrific, dystopian, Sci-Fi movie like. Sorry off topic.
Related or not, I was born with herniated diaphragm, iirc 60-75% intensities in lungs, hole in lung, and collapsed lung. Doctors thought i had a respiratory infectionā€¦ one Rainbow Babies Doctor saved my life; Dr. Cramer (spell check - he went military). I also had a birth mark covering my entire stomach basically that was melanoma and had to get it removed; i have two big scars covering my oblique and lower abs. I donā€™t feel like asking my mother right now for the exacts but itā€™s pretty on point.
As i mentioned, i am very healthy; i exercise, eat clean, have great support, an amazing SO who takes AMAZING care of me and so on. Physically (internally?) i am horrific; but i am muscular and in shape.
As i am trying to manage most to all my health problems listed, anxiety, panic, agoraphobia, sleep and insomnia; these have been a major hit to me this year. I get 2-4 hours of sleep a night on average - with 4 being good. Itā€™s also not consistent sleep, i will wake up, fall back to sleep then wake up and be up for good; cannot get naps in either. With my sinus issues, itā€™s also impossible to sleep, i cannot describe how thick and big my mucus plugs are and nasal polyps; let alone the tick nasal congestion thatā€™s never ending. Itā€™s thicker than peanut butter and almost as sticky as THC oil. The inflammation makes it feel like Iā€™m suffocating.
Due to the severe anxiety and panic disorder, agoraphobia, sleep and insomnia, my doctor has me on 2mg Klonopin daily with 1mg Xanax for panic attacks; and to help with sleep. I have to say i feel my tolerance has shot up fast and the effects are diminished. I havenā€™t been on them long too as wellā€¦ Sleep is still bad and 1mg Xanax doesnā€™t seem to do the trick when needed.
How can i upregulate my a1 GABA and NMDA antagonist/receptors to prevent tolerance and withdrawals. I have attempted to research myself but cannot understand the medical language. I have seen the mention of NMDA; a lot of it i find confusing. A lot of my research that seems ā€˜cookie cutterā€™ proven has to do with opiates and Iā€™m not looking for that.
Then Reddit has a million different answers or suggestions that may or may not work. I am unemployed and cannot afford to simply buy and try all of this stuff if you feel me. I understand some may work better than others but i have no idea where the best is to start.
Some of these Reddit posts Iā€™ve read are a few years old or older so has anyone had any success with what Iā€™m trying to accomplish?
Which is: being able to take my daily dose of Klonopin and Xanax preventing tolerance and withdraws or at least to some degree by interfering with my a1 GABA and NMDA antagonists and receptors.
I hope all my language here is clear enough for you to understand what Iā€™m trying figure out and accomplish. If I misspoke or was unclear about anything, please comment and i will do my best to explain my the misunderstanding.

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1 year ago