My partner (23 enby) of three years started taking Wellbutrin about two months ago. Things worked out pretty well! It was their first antidepressant and it seemed to be working. Their mood was balanced. They experienced a whole range of emotions but were generally happier than they had been.

Two or three weeks ago though, it seems they hit a wall. They take their meds very consistently and have not missed a single dose. Their emotions though are all over the place. When something sad/upsetting/disappointing happens, instead of a "normal" level of negative emotion, they are sent a tsunami of sadness and their depression is worse.

They are also having trouble sleeping. For example, this morning I woke up at 4 am (typical for me) to a message from them at 3 am (4 hours after we went to bed and many hours before they typically wake up) saying that they were still awake and felt useless because they are suffering. This has been fairly consistent now for the past week at least. Their doctor prescribed a med (hydroxizine maybe?) to help with insomnia, but this is also not working. The only time they have seemed to get proper sleep has been the two nights where the morning after they wake up with me because I don't have work and can sleep in.

Part of it may just be a combination of meds adjusting and lots of little disappointments. Things like their siblings having a rough time and then not being able to help, their favorite video game getting more frustrating (and therefore it not being a good distraction from negative emotions), and friends of ours being flaky on plans and disrupting our schedule (they're autistic and what routine we have is important to them).

My question for you all is this: is it possible their Wellbutrin just isn't working anymore? Should they talk to their doctor about switching to a different medication? If so, what is that process like?

I'm just so worried for my partner. I hate seeing them suffer like this, but I don't know what to do to help. We can't afford any form of therapy right now, but it is something I'm trying to figure out if they can try again soon. They had a therapist for a few months about a year ago, but the therapist said they seemed to be doing okay and had a good grasp on their mental health and recommended they stop sessions.