[in progress]

ACUTE PREDICTORS:

Predictors of ASC Dimensions 31:20 [2]

	OB	AED	VR
Emotional lability
Rigid conventionality
Optimistic extroversion
High aesthetic sensibility
Non-dogmatic religiosity
Optimistic naivety	?
Desactivity
Previous experience
Setting
Dose

^{OB=Oceanic boundlessness, AED=Anxious ego dissolution, VR=Visionary restructuralization}

^{[Note: OB and AED are the same thing experienced positively vs negatively]}

^{Dittrich, 1998; Studerus et al., 2010}

Pleasant, mystical-type experiences:

• emotional acceptance - strongest predictor besides dose ^[2]

• high trait absorption ^[1]

• emotionally excitable & active immediately before drug intake ^[1]

• having experienced few psychological problems in past month (more predictive than personality factors) ^[1]

• Performance-Related Activity (e.g. go-getting, avid, active, and energetic)

• emotional acceptance ^[2]

• emotion regulation (mindful presence, non-judgmental acceptance) ^[2]

• lifetime mystical experience ^[2]

• TOT score (relaxation, self-transcendence) ^[2]

Unpleasant, anxious reactions:

• high emotional excitability ^[1]

• low age (more impaired control and cognition, less bliss: Metzner & Hyde think it's due to a lack of experience with managing negative emotions) ^[1]

• experimental setting involving brain imaging ^[1]

OB/selflessness: ^[2]

• meditation-depth over 3 years [days?] ^[2]

• life time mysticism ^[2]

Visionary Restructuralization: ^[2]

• meditation-depth ^[2]

• absorption (TAS) ^[2]

Anxious ego-dissolution: ^[2]

• low acceptance ^[2]

Citations:

[1] Prediction of Psilocybin Response in Healthy Volunteers - Vollenweider et al., 2012

[2] Psychedelic Science 2017 presentation - Vollenweider, 2017

LONG TERM OUTCOME PREDICTORS

ASC factors associated with therapeutic outcome:

• experience of unity

• spiritual experience

• blissful state

• insightfulness

• low anxiety

Positively correlated with QIDS at 5 weeks (starting from most correlated):

I felt particularly profound

I had particularly inventive ideas

I experienced a profound inner peace

Worries and fears of everyday life felt irrelevant

I felt one with my surroundings

I experienced past, present, and future as a unity

Oppositions and contradictions seemed to resolve

Many things appeared incredibly funny to me

I felt connected to a higher power

I experienced boundless joy

I thought I would lastingly change in a wonderful way

A voice commented on every thought although no one was there

I felt full of awe

Body sensations were full of enjoyment

I had insights into the ways the world works that were mysterious to me before

Negatively correlated (starting from most anti-correlated):

Time passes slowly in a painful way

I felt threatened

I had the feeling of unbearable emptiness

I had the feeling that something terrible was going to happen

I felt tortured

I felt as if I was half-asleep

I experienced everything as frighteningly distorted

I felt paralyzed

I was scared without knowing why

My thoughts were always interrupted; I could not think anything to its end

I felt as if dark forces had overtaken me

I felt drunk

I was afraid of not being able to get out of the state in which I found myself

I felt dazed

I was afraid of losing control over myself

Leor Roseman: Psilocybin-Assisted Therapy, Neural Changes & the Relationship Between