I'm on Xeloda for maintenance, 4 g /day. Have been doing 2 weeks on and 1 off since November I think. I was told right when I started that urea based lotion works wonders for the hand & foot syndrome that accompanies Xeloda. It's done an okay job. My feet are constantly sluffing off the top layer of skin, but I don't have any sores. I think that may be because I've taken to wearing comfy wool blend socks and shoes or boots that fit so that my feet have no room to slide around. Last week I wore a looser pair and couldn't walk after like 3 pm.

My hands are doing better than my feel. Some skin peeling, but no deep cracks. I put lotion on about every hour and a half though. My hands always feel like I'm wearing nitrile gloves a size too small though, sorta like my hands are trying to break through my skin. It's a weird feeling. Neuropathy in my thumbs and forefingers only though.

But the Xeloda works, and I'm willing to tolerate it as long as possible.

Don't really have any issues eating other than decreased appetite. It's the fatigue after taking the pills that gets me. In the mornings the caffeine from coffee fires an alright job, but at dinner it really hits and I'm worthless for a few hours. If somehow I managed to stay awake past 9 it settles down and I'm tired but not feeling that extreme fatigue.