So the bugs actually started early on for me but they where only for side missions, so I wasn't to bothered by it thinking "they'll fix this soon, and I can just do these missions on another playthrough". The missions where:

The bloodshine mission in Lectra City

-sister refused to spawn just skipped to mother, sister hasn't spawned since.

And then the mission ratched up

-Again at a certain point forget where things just stopped spawning in

But now I've come across a bug that makes the game damn near impossible to finish/play, I've come across a bug on the cathedral of the twin gods story mission I'm stuck at the "open sanctum gate" part and I know others have come across this bug as well.

Additionally after respcing my character today, I can no longer use my action skill and it tells me I have points to put into my tree, but when I go to my skill tree all points have been used.

Help please?