I figured a lot of people didn't watch the twitch (you can check it out here), but I did out of an extreme need for procrastination material. The people from Twinfinite asked Edmund questions that they gathered from a reddit post earlier in the week. Here are some of the more interesting tidbits about the remake:

Rebirth details!

• Nicalis will focus on remaking the entire game (original Wrath of The Lamb) with some tweaks, and then Edmund will step in to add the new content.

• The art style will remain 16bit and the old art will not be included. Ed says that the style is getting there but needs some work, and that he will approve each piece of art.

• Isaac's design especially is a WIP. His face will be bigger than it is in the original game because pixel art limits the amount of detail they can add with items, but how much bigger is still up in the air.

• Arcades will be retooled so they aren't such a time sink, although he was unclear on how this would be done. He did say that the probability of machines blowing up will be higher than it currently is.

• In general there will be a greater incentive to spend less time on floors. Some new items will somehow be sensitive to time, which was impossible in flash. Ed's goal is that the average run time in the remake will be a little shorter than in the current game.

• Choosing between going to Sheol or the Cathedral will be more meaningful. Ed admits that in the flash version there's not much point in going to Sheol if you've unlocked the Cathedral. He hints that there will be some extra floor equivalent to the Chest after Sheol and that the choice between them will be more interesting.

• There will be plenty of new challenge runs, but no custom run option ("definitely will not happen"). Ed says he wants the challenges to actually have some reward (an unlock) and that custom runs (a la the cheat engine) are essentially about hacking the game to start with items. He feels that if this was included in vanilla Isaac it would "break the game".

• There will be some other feature that "touches" on the concept of custom challenge runs, but is "much cooler". Ed declined to elaborate, but said that it's one of the ideas he wanted to implement in the flash game, but couldn't due to technical problems. "People who want custom runs will be very happy with this feature, but in a lot of ways it can be a challenge."

• There will be no wiki-like feature, telling you what items do. Ed mentions that he doesn't like the wiki because it "kills the magic" of figuring everything out for yourself.

• There will be a new ending but Ed hasn't figured it out quite yet.

• In a response to the wiki breaking everything down, Ed wants to add secrets that will be very hard to find and will stay buried for a while.

• The stats screen is up in the air. Ed says he hasn't thought about it, but in general he wants it to stay vague.

Edit: more stuff!

• There will be a Skatole-like item for spiders.

• The remake will run "perfect". Little to no drops in the frame rate are a high priority. Fun fact, Ed actually refused to release Isaac because it had such a terrible frame rate. It was only until Tommy (the other half of team meat) took a look at the build that it got up to its current state, which Ed is still embarrassed by.

• Lemon Mishap will get a buff. The creep will stay on the screen longer and it will recharge a bit faster. Overall, Ed says that there still will be shitty items and powerful items, but some of the more worthless ones will be made more useful.

• Ed says that he "overdid it" with flying items in Wrath of The Lamb. Flying items will not get cut, but chances are that there will be no new flying items in the remake.

Trivia!

• Florian programmed much of Isaac in German. Ed will have Florian on to translate his code for the remake.

• Soul hearts going off the screen was a bug. You were supposed to only be allowed the visible number of hearts, but Ed liked the mystery of wondering how many you have left so they never fixed it. Soul hearts being able to extend off the screen will be in the remake.

• Ed dropped out of community college after some weird guy got the same grade as him in a 3D animation course.

• Edmund admits that he never really had a clear vision of the story (what actually is going on in Isaac) and that it's developed over time.