I just started taking spiro and estradiol last week (50 mg and 2 mg respectively) and I've noticed that in the past couple days my testicles have been a bit achy. At first, I thought it was because of a workout I did where I accidentally put too much bodyweight on my crotch, but it went away and then came back the next day, so now I'm not so sure. It's definitely not debilitating or anything, though I can't exactly say it's comfortable. I haven't really been tucking full-on either, just trying to keep everything somewhat flat. I'm wondering if anyone else has experienced something similar on feminizing hormones, or if it's just some kind of weird coincidence.