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If you reversed a protein's primary sequence, would it retain it's function?
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Imagine you took a sequence N - ABCD - C and changed it to N - DCBA - C.
This was a question I thought about as a first year grad student. I asked my PI and casually googled around without finding much. My gut says it likely would, unless the free termini were important for the proteins function. Anyone know something more?
Edit: sitting here thinking about it, I have a hard time picturing this protein folding correctly as it came out of a ribosome.
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