Ive only recently accepted/discovered that I have bipolar depressive disorder. In the past, I have tried Prozac which was a unplesant experience to be polite. Ive also been on a massive dose of depicoat that didnt have the effect so desired. But on this new combo of Seroquel and Zoloft, i have found that this is a combo that works for me. While it took my body about 2 months to adjust to the medication and adjustments in both sleep and appetitie. I have been able to stabilize with minimal episodes of dramatic depression. I also found that the Zoloft has been helping with my anxiety in public spaces. Though im only 4 months in. I can safely say, that this combo has been working quite well. Anybody have any similar comments or senarios? I dont know if I am the only one so I dont want to be biased and say that this will work for everyone with the same disorder. Much feedback is loved and appreciated for education!