Where would you set a sequel to Alien: Isolation? Who would the protagonist be and how would the story develop?

I would love to see the setting as some sort of luxury resort either in space, or on a planet, which descends into chaos after a tourist falls ill with 'food poisoning', it would be fun to see a kind of 'Titanic in space', perhaps with more than one surviving protagonist this time, give the player a brutal choice later on on who to save in a tight spot - perhaps giving the protagonist kids to save from the hive? Also I think this would really allow for some great use of synthetics as waiters and staff who serve on board.

I would like to see Amanda Ripley stay in the game as either a voice who helps the player via radio link or perhaps she could exist in holographic form or via records discovered by the player? Maybe she is 'Patient Zero' somehow? And let's introduce an actual Queen and final battle similar to Aliens - this would tie in great to the parenting theme and basically writes itself.