Day #4 of 150mg Bupropion XL in addition to 20mg Fluoxetine. So far, I’ve totally felt off. Headaches, nausea, “high” feeling, unmotivated, no increase in energy or libido & find it harder to focus on tasks. For the most part though, my mind has been clear, depression & anxiety minimal to none. Sleep has been not the greatest either. Appetite also has decreased. I’ve read feedback that this med takes at least 2 weeks to start working. These side effects though 😩. I’d be willing to bet I’m also not taking meds early enough too. I work 2nd shift, so when I get up 1st thing around 10am, I take heartburn meds 1st (protonix) wait an hour then take the Fluoxetine & Bupropion. Perhaps I should take the psych meds 1st?? I’ve read that consuming caffeine with Bupropion doesn’t work out for some & I have a few cups of coffee in between protonix & psych meds. Just wanted to share my experience thus far & ask if anyone has had similar symptoms.