Coming soon - Get a detailed view of why an account is flagged as spam!
view details

This post has been de-listed

It is no longer included in search results and normal feeds (front page, hot posts, subreddit posts, etc). It remains visible only via the author's post history.

8
What makes LSD so hard to synthesise???
Post Body

So I know LSD is said to be very difficult to synthesise and a pain to work with in general unless you have some professional and expensive lab but what makes the synthesis so difficult. On paper it doesn’t seem that difficult and so I had been thinking about attempting it synthesis from LSA ( extracted from hbwr seeds )

So I know you can’t use an alkylating agent like ethyl iodide because it would probably attack the other parts of the molecule too like the secondary amine, but what about just using something like sodium hydroxide to hydrolyse the amide to its carboxylic acid, (lysergic acid), would it be too risky damaging the unstable molecule? Would it be possible to do this without having to heat it up too much? Usually for a hydrolysis you’d heat it up with a acid or a hydroxide and reflux it however LSA isn’t really that stable so could using KOH, HCl or maybe dilute H2SO4 at room temperature for a few days work?

Then with the lysergic acid I could make some diethylamine and then react the two in a condensation reaction in the presence of phosphoryl chloride (witch i could make myself from phosphorus pentachloride) to hopefully yield the LSD

So what’s the hard part? It seems easy on paper, and I know it’ll be much harder in practice but where does it get hard?

Comments
[not loaded or deleted]

For people always assuming an LSD synth is almost impossible, they fail to account for bands or hippies that could pop up in a town and crank out LSD

That is both true and not entirely on point. Hippies evolved from Beatniks and Beatniks were often rather accomplished academics in their own right. It was something of an intellectual caste system with the turbo idealistic older guys having a vast teen and mid to early 20s apprenticeship and distribution network. One thing that comes up over and over again when interviewing veterans of the time is that even very embedded people defacto never knew where it came from except "those people one town over" or "my contacts that never told me anything" to the point some began to believe it was airdropped by aliens.

...and then there's Pickard who categorically refuses to talk chemistry with anyone and will likely take his entire process to the grave cause they fucking broke him in prison.

For raw materials, can't you just cultivate ergot?

Annoying as hellllll process. Once you introduce a complex living organism into the equation you're dealing with a wholly different skill & requirement set.

The core problem is that you gotta believe in LSD over every other possible psychedelic/need to be in a place where distribution of any other psychedelic is hard but running the operations for the creation of acid is feasible. It's as much a matter of locale & belief system as skill and that narrows things down a fair bit. Ironically enough lessening penalties on drug possession are making it less likely for people to make it cause a big thing that made acid such a smash hit was how little material you needed to the point where acid was the very first substance to use the postal service and later the internet in a major way for distribution.

Author
User Disabled
Account Strength
0%
Disabled 5 months ago
Account Age
3 years
Verified Email
Yes
Verified Flair
No
Total Karma
15,401
Link Karma
6,023
Comment Karma
9,342
Profile updated: 1 day ago

Subreddit

Post Details

We try to extract some basic information from the post title. This is not always successful or accurate, please use your best judgement and compare these values to the post title and body for confirmation.
Posted
1 year ago