At present a full 12% of TK play (Up to 30 in Plat ) is in the bot lane as ADC. Of which, presumably the vast majority of it is the Fasting Senna strat where he farms and Senna supports.

One obvious question I have is, will the Rework kill fasting Senna?

Basically none of the changes seem optimal for the Senna combo. His ability to protect Senna with his W was one aspect of it that's being totally gutted. Another aspect would be his wave clear, which has also been ground stomped by his damage and devour nerfs.

When you get right down to it, Senna needs peel more then engage.

So, while we all might be debating if Top/Jungle/Sup Kench is dead...the likeliest casualty of all seems to be ADC.