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It’s known that amphetamines increase serotonin (although not to the same degree as dopamine)…. Which makes me wonder: could a big part of amphetamine PAWS be not only related to dopamine, but serotonin? Specifically the mood and reward response part…
I’m just thinking, as I work with a new psychiatrist, about the best supports during PAWS and it never occurred to me that a big part of this may not just be dopamine, but serotonin.
Total speculation, but it makes me wonder if a Wellbutrin and SSRI combo is actually the best option for the first 2-3 years after amphetamines.
I’m going to ask my psych and report back.
40-60% response rate is decent considering the difficulty with treating mental health issues.
Correct, but it’s fair to infer that PAWS is essentially a term to describe the long lasting dysfunction in the seratonin, dopamine, and norepinephrine systems.
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- nature.com/articles/1395...
Basically that using an SSRI reversed anhedonia in people withdrawing from amphetamines.
Hard to draw big conclusions, but lends credibility to the idea that an SSRI and Wellbutrin has efficacy for PAWS.