I'm on lethal mode. So for me it's the ferals,jugs and black hearts. Single ferals are no problem to me no more, but a horde (3) are a major problem. If I'm driving and see 3 I lead them to some mines or if I'm not close to mines, I get on top of a vehicle and just start blasting their heads. Only time a jug is a problem is when I'm near a plague heart takin care of business or a jug coming to my base to start a raid just cuz im pulling up to my base. Now Black hearts are always active. So they will always cause infestations 24/7 if you don't take care of them. Which is kinda hard because black hearts health is different than a regular plague heart and they cause plague zombie to get stronger and damage you while walking in the circumference of the black heart zone. Other than that I have no struggles on this game like I use to. I'm on my second map and got 6 hearts left.