After the Liberal Alliance's landslide victory in the Chamber of Deputies and Senate, Alessandri has reconstituted his cabinet, in order to adapt to the change in composition of the coalition and to the increased liberties afforded by his majority. The cabinet was formed in December 1921 when the new Congress was sworn in.

The standard reshuffle was accompanied by an expansion of ministries to fit with Alessandri's economic and social policy: the ministry of Lands & Colonisation has been split off from the ministry of Foreign Affairs, the ministry of Industry has been broken up into constituent parts, as has the Ministry of Jusice.

Alessandri's picks were guided by political reality as well as technocratic principles - the minister of Public Education is a professor, the minister of Transport is a noted railway engineer, the minister of War is a veteran and the son of noted statesman José Manuel Balmaceda.

Most controversially, Alessandri has appointed a female minister: she is the first in Chilean history, and in fact in the history of all Latin America. Gabriela Mistral, a professor and poet, caught Alessandri's attention for her work in these areas and her political activism. She has been appointed to head a new Ministry of Woman, which will be in charge of designing policy around increased women's rights.