I took it today about 5 hours ago and I'd say about 1 hour ago I started having a severe flare up in my left ankle. It feels like it's broken which I know it's not because I wasn't walking or anything. I can't put any pressure on it and when I tried to walk to the kitchen to get some water I almost fainted. Started getting a headrush and my shoulders started hurting. I'm about a week and a half late taking my injection because I had to get a new debit card and the bank took forever to send me a new one. I wonder if that's the case. The only thing new since my last injection is I started taking an antidepressant but I don't think that would be the issue.