I’m about to retrial Zoloft after taking it briefly and having increased panic symptoms. I’m diagnosed with both PMDD and OCD, the latter lwaxes and wanes but gets significantly worse in my luteal phase. Prior to developing OCD, my main luteal mood symptoms were extreme irritability (due to heightened anxiety, and could fly into a rage at the drop of a hat) and intrusive thoughts/negative self talk. This cycle for whatever reason was not as bad, and I will be restarting Zoloft next week. But as I was going through the last few days of luteal and feeling/noticing the negative thoughts creeping in, I just have to wonder how an SSRI going to significantly help… did anyone see a noticeable decrease in the intrusive thoughts and negative self talk after starting SSRIs?