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Suitable Non Nucleophilic Base to use?
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Hey all

https://preview.redd.it/snzp1kq4a5761.jpg?width=524&format=pjpg&auto=webp&v=enabled&s=c1c5238072f4ffbeb29d91fda4f8a4e56814f70a

I am a PhD student in London and am asking the hive mind here for some advice.

After Christmas I am planning to carry out the following reaction, without any literature precedent by following a general protocol which I have been using over the last month now. The 3-Bromobenzylamine is sold as the .HCl salt. Naturally I will need an equivalent of base in the reaction to soak up the proton yet this base has to be non nucleophilic. My initial thoughts are to use equivalents of Potassium carbonate or a sterically hindered non nucleophilic base such as DBU. Can anyone give me some advice if you think these would be suitable or if you have any other suggestions.

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3 years ago