Hello!

My quarantine passion project has been a series on my blog I have been calling "Obscure and Unknown", where I delve into medical literature and other sources to find interesting hallucinogens or prospective hallucinogens with scant records of human use. Some other articles delve into hallucinations generated by drugs in uncharacteristic or little-known ways. Some of these drugs were briefly developed as one off batches of research chemicals. Many were tested as medicine but were abandoned and forgotten due to interesting "side effects", which I interpret differently. Still others show interesting properties in animal and receptor affinity tests that may be able to be extrapolated into interesting substances for humans.

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Also note because of the scant data, I am wary to say anything definitively. I am wary to outright say any of these substances will give you a fun trip. Much of what I write is conjecture, but nonetheless I hope it will serve as a basis for further investigation! Also whenever I say testing here I don't mean "testing" in the rc sense, I mean actual scientific studies.

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I would like to clarify that I have no formal background in organic chemistry (got a C- for my required credit actually), pharmacology, or neuroscience. I apologize if I don't always use the proper terminology. If there's anything I got egregiously incorrect please let me know! I had to teach myself a lot to write these, the articles may be a bit long and dense because I try to take the time to give a rudimentary explanation for some of these concepts that I had to teach myself. I'm hoping they will be accessible to a wider audience while maintaining their integrity.

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There is still so so much to explore ! And there will always be so much to explore! This is by no means done, I still have a large backlog of substances I have found that I still need to investigate further and write about (Lophophine, 8A-PDHQ, Cryogenine, rare Diarylethylamines, Halogenated Tryptamines, HA-966, Indazole Tryptamines, Selfotel, Grayanotoxin, Traxoprodil, ZDCM-04, 7-Chlorokynurenic acid (maybe)), but I am definitely open to suggestions for others!

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If any of you are interested in studying these further- please heed the warning at the top of each post.

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Here is what I have so far:Dioxolane Dissociatives - (Etoxadrol, Dexoxadrol, WMS 2539, WMS 2508) A series of NMDA antagonists studied as anesthetics that demonstrated remarkable hallucinatory properties that led to them being abandoned and forgotten

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Benzomorphans - (Pentazocine, Phenazocine, Cyclazocine, Alazocine) An interesting series of drugs that act primarily as opioids, though they are likely also NMDA antagonist dissociatives. Interestingly, they act on the K-Opioid receptor similar to Salvinorin A, and case reports cite vivid open eyed visuals and dissociative-like effects.

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Halogenated Mescaline Analogues - (Trifluoromescaline, 2-Chloromescaline, 2,6-Dichloromescaline, 2,6-Dibromomescaline) An interesting series of forgotten mescaline substitutions- Trifluoromescaline may be extremely long acting, while 2,6-Dibromomescaline seems to be intensely visual.

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Analgesic Psychotria Alkaloids - (Hodgkinsine, Psychotridine, Pscyhollatine) Psychotria is best known for P. viridis, which contains DMT. However, there are several species (most notably P. colorata) that have interesting analgesic properties, which (though not confirmed) seem to be attributed to mixed opioid-NMDA antagonist activity. Though these pend further testing, this may be a naturally occurring dissociative!

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Butyl Tryptamines (Part 1) - (MBT, DBT, NsBT, NtBT and 4-HO-DBT) Part 1 of a long post about the butylated route of tryptamine substitutions. Shulgin said "Butyl is futile", but many of these compounds seem active, though not exciting. It still warrants further investigation. Part 1 delves into some of the specific ones Shulgin tested and a further analysis of them.

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Butyl Tryptamines (Part 2) - (NBT, 4-HO-DiBT, 4-HO-DsBT, and other possible compounds) This is Part 2, where I look into Butyl tryptamines that Shulgin never worked with. I then go on to list out all of the possibilities for butyl substitution and make conjectures based on structure of which may prove to be the most interesting psychedelics.

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PEA-NDEPAs - (TMA-2-NDEPA, DMPEA-NDEPA, M-NDEPA, DOM-NDEPA) A bluelight poster synthesized and self-tested a series of phenethylamines with extremely bulky substitutions that ultimately resemble a lysergamide. Some appear to be very potent psychedelics!

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Deliriants of the Edgewood Arsenal Human Experiments - (BZ, EA-3443, EA-3580, EA-3834, and EA-3167) These are drugs that should never be tried by people, they are anticholinergic deliriants that were developed by the U.S. military as potential incapacitant chemical weapons and tested on army volunteers. They are all extremely potent and long lasting, with one compound lasting up to 10 days.

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LAE-32 Another one from the annals of the U.S. government, this lysergamide was briefly studied during project MKULTRA. It appears to be a much less potent lysergamide, dosing >1 mg, with curious antipsychotic effects that weren't investigated further.

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Tricyclic Arylcyclohexylamines (PD-137889, PD-138289) What happens when the 2 main rings of an arylcyclohexylamine are constrained into a tight 3-ring structure? Potentially potent dissociatives that certainly warrant further investigation into substitutions.

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Tricyclic Tryptamines (RU-28306, NDTDI) Some redditors may remember these unique highly potent "psychedelics" as very lackluster but I delve into them for the sake of looking at their implications within structure-activity relationships. RU-28306 particularly appears to be an odd sedative.

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2-MDP A simple little dissociative that resembles an anticholinergic. It has only been tested in animals but behavioral effects seem to be similar to normal dissociatives and it appears to have an odd long lasting stimulant effect.

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Ergometrine and Methylergometrine Two lysergamides (one of which is actually a WHO essential medicine) with effects strongly reminiscent of LSA.

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Antibiotic Induced Hallucinations A detailed look at the delirious hallucinations caused by common antibiotics. While rare, it is interesting that such a mundane drug can have such powerful hallucinatory effects! Definitely not one to try for.

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Aptiganel An NMDA antagonist developed for treatment of stroke that was abandoned for its dissociative hallucinatory effects. The failure of this drug led to the collapse of the company that developed it.

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Mefloquine An antimalarial drug whose clinical trials were rushed. It was later discovered that it could induce powerful psychosis and deliriant hallucinations in some patients, sometimes permanently (!), which led to a series of murders and suicides. An catastrophic cautionary tale about rushing medical development.

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CNS-5161 Another dissociative that was abandoned during its medical development for dissociative effects. This is actually the first one I wrote, like 4 years ago before reviving this project recently. Probably due for a rewrite as it no longer meets the standard of the other ones.

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So which of these do I think have the most potential for further study?

-The Dioxolanes show a lot of promise as really interesting drugs, these are what I would most like to see researched further. They also have a lot of analogue-building potential.

-Benzomorphans seem interesting too, though they may be dysphoric in their effects

-The halogenated mescaline analogues all show promise

-The Psychotria Alkaloids MAY be interesting but not enough data exists to say anything for sure right now. Further testing (and I mean lab testing, not "testing") must be done on them

-The following Butyl Tryptamines: 4-HO-MBT, 4-AcO-MBT, 4-HO-MiBT, 4-AcO-MiBT, 4-HO-MsBT, and 4-AcO-MsBT, 4-HO-EBT, 4-AcO-EBT, 4-HO-EsBT, and 4-AcO-EsBT

-PD-137889, PD-138289 show promise, and have a lot of possibility for active analogues through all sorts of substitutions

-DOM-NDEPA, the DOM analogue of the PEA-NDEPA structure, and by proxy pretty much all of the DOx analogues of the PEA-NDEPA structure. This one was the most potent and had the most interesting effects.

-2-MDP may be interesting too, animal studies show promise

-CNS-5161 is also probably worth exploring further

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Now I would like to reiterate- just because I say these may be interesting, don't go out and just try them willy nilly! A lot of these should first be tested in as clinical setting as possible in as controlled a manner as possible, some absolutely need further lab tests before they should ever be administered in humans, and some should just not ever be taken by people at all. I hope this can open them up to further discussion and investigation!