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So I have MDMA induced brain damage from, taking MDMA regularly at ridiculous doses weekly multiple times a night from ages 14-17. I’ve been speaking to someone who seems very knowledgeable on the subject and they’ve suggested a stack to help fix my issues that stem from this. I have symptoms like mild-strong anhedonia, depression, anxiety, very bad memory issues cognitive issues like slowed thinking speed, little to no inner voice and concentration issues. This all compounded into social issues as well as I feel I’ve lost my peronakilty. I’m 21 years old and autistic and never used to struggle with these issues, I could find enjoyment in so many things and I haven’t had a hyper fixation in years now. I’ve been off MDMA for 4 years now and I’ve seen some improvement but that not that much. I just want to be better again.
He suggested this stack:
SJW 300-600mg (A.M) -Lithium Orotate 20-25mg or Lithium carbonate 300mg (A.M) -NA Semax Amidate 600-900mcg (Split into 2-3 doses) -Cerebrolysin Intranasal or IM. (A.M) -High dose Ibuprofen 1600-2400mg split AM and PM -NAC 1000mg before bed -9MBC 20-30mg SUBLINGUAL for a month. (I took 9MBC with NAC before bed)
This was his reasoning for it:
Lithium works through many signalling pathways, an important one being the Wnt/B-Catenin pathway via GSK3B inhibition. This pathway regulates the growth and differentiation of neurons.
Cerebrolysin induces many neurotrophic factors, and activates the sonic hedgehog (SHH) pathway.
SHH Wnt various transcription factors (FOXA2, LMX1B, PET1) are extremely synergistic
High dose Ibuprofen inhibits the signalling pathways (RhoA/ROCK) that CSPGs and MAIs signal through. CSPGs and MAIs are the main barrier’s preventing regeneration.
NAC before bed will inhibit oxidative stress and neuroinflammation. You have neuroinflammation which makes sleep unrefreshing.
9MBC regenerates dopamine neurons. Will be very synergestic. Take sublingual. I think you should stick with 300mg SJW with this.
Can anyone help?
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