HDAC inhibition (Trauma/Fear Reducer)

given it's strong enough and hits the right HDAC type (there are multiple, just like there are multiple kinds of serotonin/dopamine receptors), can 'extinct fear' in human memory, something not much else can do, essentially weakening trauma significantly.

Vorinostat is the only known HDAC inhibitor to be strong enough to do so. Yes there is butyrate and valproate, but both of those are not strong or acute enough to work. HDAC works via enabling your memories to be overwritten over for a short period of time via some mechanism I personally do not understand. Check out the link at the end for a more scientific explanation on reddit. Here's a quote from that post.

The HDAC inhibitor holds open the transcription window during memory formation, enabling the real-time reevaluation of the old memories, and the ability to strongly consolidate the present moment into long-term memory. This double whammy makes sure the present moment is prioritized. HDAC inhibitors, while on them, also let you more deftly analyze any situation you’re in due to nearly everything during the session being written into long-term memory in one way or another. This allows for a relatively extraordinary amount of learning power. They give you not only a clean-slate emotion-wise, but the memory power to make more intelligent decisions.

Risks

Here's another quote before I give my own input.

First, I must give a general guideline and disclaimer about HDAC inhibitors. These are not piracetam… we can’t just take some and see what happens. These compounds, so far, are only used for cancer, they are relatively in their infancy for any use other than this, and are very powerful compounds. Please educate yourself on how they work and how exactly they should be used for what you’re planning on using them for. HDAC inhibitors can arrest the cell cycle (which is how they kill cancer), so they cannot be taken every day. HDAC inhibitors should also be taken at dosages much less than those recommended for cancer. They will still be quite strong enough for our uses at lower dosages. Vorinostat, for example, is taken at 400mg every day for cancer, but for memory enhancement one would take 150mg once in a four day period maximum.

That being said, HDAC inhibitors can be taken safely acutely, and have some incredible effects due to their unique mechanisms. Now let’s get to the good stuff!

Vorinostat carries some RISK. After all, it's an approved anti-cancer drug at 4 to 8 times the dose, and cancer drugs are risky because cancer is very lethal, so worse side effects are tolerated. At normal, daily dosages, it's meant to stop cell reproduction (I think t-cells), which obviously is not something to mess with, so avoid those effects by sticking to recommended dosages and dosing weekly at most.

1. Pharma grade is pretty impossible to get and expensive, so you have to rely on chemists, say in china, to make/sell it to you. Your quality controls from buying from a lab is never guaranteed, and it's not intended for human consumption. Now, if you trust who you buy from, you should be ok, just be aware.
2. Side effects while seemingly rare, can be bad. Out of everything I've read, one person allegedly got permanent tendon pain after 4 uses over the course of a month. I have no idea how it onset, but, this is the only person to have permanent damage from that out of the tens of thousands that have tried it for these purposes. I guess the last risk is that it doesn't work, but I think it's very much worth trying out. Just treat it with respect. I would wager at least 60% experience benefits, the rest not so much, and maybe significant side effects .1%. There is no data, but in my non-medical opinion, it's worth it.

There is nothing like vorinostat, but you NEED to be aware of the two risks mentioned. I am not giving medical advice (obviously), but I think good risk reduction would be, first, to test for a bad reaction, say take 5-10mg it, then try 50mg then 100mg, which is the highest dose for fear extinction, though 50mg should work too.

The idea behind using vorinostat is that you take it while you are clam and relaxed, wait 30-45 minutes for it to kick in, and then you reminisce and reflect on your anxieties and traumas that are deep within your memory, it should last an hour before your memories close again. You essentially replay these bad, traumatic memories and tell yourself why you should not fear it, and maybe spin it in a postive, non-stressful way.

After the second or third session, the trauma, whatever that may be, should be significantly weakened. It is also said whatever you do during the session is imprinted onto you. So I always made an effort to do good but still relaxed things while on it, and it may have helped.

It is said that it can't make anything worse, as your current calm and relaxed state in your 'session' can only overwrite negative or fearful things. There are no reports of fears being made worse because of this.

My Experience

For me, it removed my trauma related to hating drugs (it's complicated, but this trauma really has been a problem for me in the past year, trauma can be weird),

and it made me pretty much not care anymore about the rather stressful events of the past year, it also helped somewhat with social anxiety. It completely made me stop worrying about these things and I feel like a brand new person with a new handle on life.

Now that some of my traumas are gone, I'm able to love a girl I've crushed on for so long, able to be focus my time on life instead of worrying about things that did not affect me, and I have less social anxiety.

You have to space it out by at least a week and observe for any side effects, like I said, the single tendon damaged individual is real, but for me and a lot others, I feel fine and brand new.

There is no other nootropic or drug like this. I implore you to read people's experiences on reddit or longecity. People curing or weakening their social anxiety is the biggest one, but trauma comes in all forms and odds and for me, I am a somewhat sensitive person and this really helped me be better without therapy. If you can attack the trauma from the root source, your memories, memories that hold fear your brain wants to remember for the sake of survival, that it does not want to rid of no matter how useless or counterproductive it is. And even if it does not allow you to 'wipe' all the bad, it gives you a chance to not be frozen or burdened with emotions when trying to approach the problem.

In fact, there is a correlation in humans between the time a long-term fear memory has been in existence and how hard it is to overcome. The older a fear memory is, the harder it is to use clinical fear extinction methods to overcome the fear. In most cases, the fear memory becomes stronger whether the trigger is still there or not, because the fear memory is so strong that whenever it is recalled and reconsolidated, the additive effect of reconsolidation is always greater than the realization that there is no longer an actual threat, and that the trigger is in itself harmless.

It's the best thing I've ever tried and I am amazed by what it has done for me. My experience however is not indicative of what your experience would be. For some people it did not work. Do not buy something just because one post says this has #changedmylife. I have bought so many ineffective and benign supplements doing this, so you need to read read read to get an idea of how effective something really is for people in general. There are no statistics on non-response or side effect rates, so again I implore you to read online about it.

I would not talk about how to buy the stuff here. Answers I think can be found online, but I think this subreddit is for intelligent scientific discussion, not blatant sourcing or recommendations of remotly risky things without caution. Plus, that should be part of your reading process in understanding this potentially beneficial chemical.

Please ask any questions below.

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