I've created a bunch of plays, most work great with a competent quarterback, some even better with a guy like Troy Smith who mostly hits the short to intermitten routes. Heres a few of them.

Shotgun 4 wide with a rb.

I personally overload sides to help with rubs and setting up longer or shorter routes. I put wr1 on the left as far as i can set him. 2 is inside him a few yards. 3 is inside of him a few yards and 4 is far right. I usually go playaction, wr1 runs a slant. 2 wheel outside. 3 either a streak or a post to distract the safety and 4 either a streak or slant if i want to give the qb a second quick option.

same formation, 3 runs a quick out, 1 runs a medium in and 2 runs a deep out or in while 4 runs a streak.

same formation: 1 runs a quick in, 2 runs a deep out and 3 runs a medium out while 4 runs a slant.

flip formation, wash and repeat.

If i am going for more of a run attack, i'll go under center in either the singleback big formation or single te.

If i go singleback te, i'll put receivers in a lined bunch formation, the order doesn't really matter much in this case, but i'll put one wr closer to the LT maybe a few a square away, he runs a post, the one next to him runs a drag and the outside wr does a cross, the te then runs a quick out with playaction going left, and the qb rolling right.

same formation: te runs a medium out to give the playaction time to work, the inner wr runs a drag, wr 2 runs post, outter wr runs a cross

same formation: inner wr runs the post, wr2 runs wheel, wr 3 runs post, te runs a corner.

Inside the 5, i love reforming the goalline, so i'll move te1 next to te2 just off his back foot and move te3 to the line or a hair back so long as it's a legal formation. i can't remember the plays name, but essentially te's 1 and 2 run the designed route bc it works best for them to both run short and medium crossing routes, te3 gets most of the love on this one bc he runs a slant. Since usually my te3 is my slowest te, the slant is open 80ish% of the time and the defense follows the bigger threats across the field.

Finally, I do enjoy a good mobile quarterback, but subbing the rb in works as well. I go with the qb blast and i'll shift the te's outside to a similar formation as what i used earlier, except I put three on the left and two to the right. It forces the defense to spread (in man) or at least shift out a little in zone. Thus, creating a lane for the qb to run in. Now, this one seems to work really well with a guy like Josh Johnson or troy smith, primarily because they are the faster qbs in the game in the beginning. however, assuming your rb has decent bcv, he should still get some decent chunks.

I ran a few variations of this play in my last play through, leaving the te's in their positions on the line and motioning te1 just behind the LG (more where the FB lines up in the strong or near formation) and it worked relatively well. He eats up the first guy through and Johnson could dance around and pick up 7 nearly every time. However, as with anything, run it too much and it fails.

These are just a few of the formations and route combos i run, i have a ton more, but hopefully these can help others or at least spark some creativity in play calling and/or sharing your created plays.