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Prodromal MS: Early set of symptoms and signs (referred to as prodrome) such as urinary, gastric and intestinal disturbances, headaches, insomnia or fatigue that may be predictive of early detection of MS. More research is needed to define prodromal MS since such symptoms may appear 5-10 years before the first demyelinating event.
Clinically Isolated Syndrome (CIS) is the detection of visual demyelination and a series of related symptoms. CIS is symptoms presentation prior to confirmed or definite diagnosis of MS. If the lesion is detected in the brain, it is categorized as Radiologically Isolated Syndrome (RIS).
Clinically isolated syndrome is one of 4 phenotypes of MS. The other 3 are RRMS, SPMS, and PPMS
Source: The MS Blog
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