Hi, folks! I'm having my (likely last) Tysabri infusion tomorrow and switching to Kesimpta...but I'm not sure I should anymore.

Tysabri has kept me from having any detectable disease activity and I've had no progression in the 5 years since I've been diagnosed. That being said, I'm so tired of IVs. I'm so tired of being tired from infusions. I'm so tired of the malaise that I occasionally get. I'm so tired of having to work around an infusion center's schedule. So I asked my doctor about switching to Kesimpta and she was very encouraging, said she has a lot of patients on it and it's great.

Now that it's really happening, though, I'm so afraid. There isn't really any going back because Tysabri is contraindicated in people who have a history of immunosuppression (doctor said it wouldn't be completely off the table, but that it's risky). I have anti-vaxx family members, so I would need to be more careful around them with the attenuated vaccine response. I'm also just afraid of the unknown.

Has anyone made this switch? Even if you haven't...any advice or thoughts? I'm afraid of making a choice that I can't really undo, so just looking for any words of wisdom or even just a sympathetic ear.