I'll start off by saying I know combining dissociatives may be more neurotoxic than doing one on its own. I do not currently plan on making the combination a regular occurrence. 

That being said, I have not done Memantine in months, and I did Nitrous for the first time (and the only time I've done it) over a month ago. I've also only taken Memantine a handful of times, and I think the most I've done is 100 or 125mg. 

Given my low tolerance, how much Memantine should I take before I use my Nitrous? And how long should I wait after taking the Memantine before using the Laughing Gas? 

I don't mind M-holing, but I don't want to hole from the Memantine alone. (Ie, I don't want to be holing for several hours.)

Also, how long before I use the Nitrous should I take the Memantine?

Thanks in advance. And happy Halloween!