Personally I have quite a few things I'd like to see.

Alignments to matter more. Whether it be Strange Journey style where your demons alignment matters more in battle, or if there's just more unique stuff to each route. I wouldn't mind if all the different routes are drastically different, rather than only having a different final dungeon/boss. And on top of that, I'd like to see Neutral or True Neutral not be some kind of golden path. Make Chaos and Law more tempting to go with, and have them be better than "genocide lol".

A talking protagonist. I'm not a fan of silent protagonists at all. If they're keeping silent protagonists (they very likely are, let's be honest here), I'd at least like to see an option for a female protagonist. Since they're not talking anyway, I'm actually surprised we don't have this option yet.

I wouldn't mind a mainline game to not take place in Tokyo. I think the reveal of Tokyo and stuff is amazing in SMT IV, but I often find myself wondering about what the game would be like if it stuck to the Mikado setting. I know Strange Journey exists, but I'd like to see a main numbered entry.

So, what are your wishes? Discuss!