This is just my theory that is open for discussions. Some may be obvious so just bear with me.

My theory is that after strange casts the spell to help peter, it sort of messed up the universe wherein it opened a portal that transported villains of spiderman. Dead villains since strange mentioned they all died fighting spiderman but I don't think everyone died fighting spiderman maybe they had issues with spiderman that is why they got transported . And the objective of both spiderman and strange is to like have them go into a portal that gets rid of them from their universe. They both have a time limit to get rid of those or else it will destroy their universe/timeline (as you can see in the trailer the blue lines across the sky). Those blue lines might be the indication that they are failing and leading to multiverse of madness and at the same time the last episode of loki wherein multiverse is broken. It has been said in an interview that the movie will be "dark and sad", meaning it might not have the happy ending or save the day ending leading to multiverse of madness.

-About the one in the trailer when strange says they are starting to come through and blue lines appears in the sky it might be the one when both andrew and tobey shows up or lizard and sandman comes out.

-The box that both peter and strange keep on arguing about might be the one that can remove the villains or bring the other spidermans from other universe. Maybe peter had the idea of calling for help from the other spidermans that's why he is trying to steal it from dr strange and when it comes to dr strange's mind it is too dangerous because instead of having backup they might get villains or even bad versions of spiderman.

-My theory for the connection of morbius to venom to main mcu. Morbius is in the same universe with venom since they mentioned that situation in san francisco pertaining to the events happening in venom. Then venom, (SPOILER) is really in the same universe with morbius but at the end of venom 2, they are transported to the main mcu. Leading to seeing Spiderman's identity to being revealed and that's when venom said he hates that guy or looks tasty (pertaining to spiderman). He might have said that because the road that eddie and venom are on is to like catch bad guys. And seeing spiderman on the news saying he is killer maybe made venom angry to catch him. They became like a vigilante at that point.

• How did venom teleport to main mcu? It's either the moment dr strange and peter messed up in casting the spell or after the events of nwh and beginning of multiverse of madness.

• If morbius is in the same universe as venom, then what about the spiderman graffiti on the wall with the saying killer on it during the trailer of morbius? I think they had their own version of spiderman in their universe who probably killed someone. And maybe that is why venom had the feeling of hating spiderman since it reminds him of something from his universe.

Will dr strange and spiderman be successful? I think they will successfully get rid of the villains but it was already too late and there goes multiverse of madness.

open to questions and discussions while waiting for NWH 🕷️