I was prescribed LDN for Long Covid.

I started at 1.5 mg, and the first few days I had a huge burst of energy, but a slightly unnerving one, like I'd drank too much coffee. It also seemed to be accompanied by irritability and anxiety. I don't drink caffeine anymore, haven't for years, but it felt like that.

This jittery energy burst dissipated after about a week of being on that dose.

Then, today (~2 weeks after starting LDN), I bumped up my dose to 2.25 mg and once again I am feeling that odd surge of energy. Super keyed up. I'm even getting restless legs, similar to when I've been anti-depressants in the past.

It's manageable, I think. I'm going to stay on it. It's the only thing I've found that makes a dent in my Long Covid symptoms. (Seriously: I’ve had so much energy from the LDN that I feel like I need to exercise or do yard work to burn it off, which is nuts considering my energy has been garbage for months during LC, like a small hill could make me winded for example.)

I think I am going to stay at 2.25 mg for a good while, see if this over-caffeinated feeling dissipates like it did for 1.5 mg. But then I'm not sure if/when I should increase the dose. I increased from 1.5 mg because I felt like, though it was helping, it wasn't completely eliminating my LC symptoms. (But then I've read it really isn't supposed to be a cure.)