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Why doesn't LSD have a comedown when receptors are down regulated so much
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Like the title says. Tolerance skyrockets so much because of receptor down regulation, and I also remember reading that the receptors actually get sucked back into the neuron as the LSD is trapped in the receptor and can only be metabolized inside the cell. How come that not affect us negatively the days after the experience like other drugs, but actually produce an after glow for most?
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