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I've been an insomniac all of my life. I'm almost 40 now and it's still an issue.
I started experimenting with GHB for sleep (like xyrem) and found it was amazing...except for the rebound. I would wake up 3 hours later and it would be impossible to fall back asleep. Of course I could take a second dose, but that would leave me with 6 hours of sleep which was not enough.
I tried many methods of blocking this surge (high dose magnesium, agmatine, memantine, l-theanine, other sleep aids...nothing really worked, though it looked good on paper)
At one point I was studying the pharmacodynamics of pregabalin / gabapentin and noted that their main mechanism of action is blocking or dulling surges of excitatory neurotransmitters (glutamate etc).
Was feeling desperate one night and combined 300mg gabapentin with 2.5ml GHB.
I slept through the whole night.
I've since experimented with this over a dozen times and it works consistently. I went from waking up 100% of the time to 0%...much more than placebo or a small effect.
Does anyone have experience with this?
I'm surprised it is not mentioned anywhere as it is quite incredible how well it blocks the rebound.
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- 5 months ago
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