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Prosocial/Nootropic/Antidepressant drug recommendations
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I'm looking for some drugs I can take at school and work to make me more crisp and social. I have a looming depression which results in a thick brain fog and gloomy disposition. With drugs I can temporarily become the person I believe I should/would be if not for depression.

I want something with fairly high salience but nothing that would make me incapable of working or thinking clearly. Please don't say "exercise" or "meditation" or "therapy" - I appreciate the sentiment but I already do those things and I'm specifically looking for DRUGS to take.

My current go to is just basic Adderall. It's as good as I've found overall. However, tolerance can build quickly and taking it daily I feel is very stressful on the body. It also annihilates my appetite and makes me very aggressive.

Kratom, Tianeptine, Tramadol, and Hydrocodone are the only "opioid" substances I've tried. While they do have a positive effect on my sociability and overall disposition, they make me extremely nauseous (even with tons of Zofran) and have a quick tolerance build up. They also make me feel a bit dull.

GABAergic drugs such as benzos, Pregabalin, Gabapentin, Phenibut, or Kava don't work for me or just put me to sleep, so I can't take them to socialize or do work.

NMDA antagonist drugs like DXM, Memantine, and Ketamine work extremely well as prosocial substances, but are stupefying to the point of not being practically useful.

Basic stimulants like Caffine, Modafinil, Yohimbine, Nicotine, or DMAA are effective, but above all else cause irritability and a lot of the stimulation is peripheral (fast heart rate, sweating, jitters). Net sociability is unchanged due to increased irritability.

Cannabanoids are simply too stupefying to use outside of a recreational context.

Any kind of prescription serotonin/dopamine/norepinephrine reuptake inhibitor does nothing. May as well be a sugar pill. I've tried 6 different SSRI/SNRIs and Abilify.

Microdosing LSD or shrooms is placebo in my opinion but that's up for debate. Either way I've tried both and they don't work for me.

My current ideas to try next: anabolic steroids, MAOIs like Parnate or Nardil (anecdotally, these are a lot more potent than standard reuptake inhibitor drugs). I feel like I've tried most things but there's gotta be something else out there I could try that I haven't thought of.

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6 days ago