I was never using more than 20gpd, normally I used 10 or 15gpd. I was months on before I was months off again many times. Started this dance maybe 2019 but only 2021 I really had times where I consumed it on daily basis. Then again for times for months none, for months on, for months none, … and so on.

During all this time I must say Kratom never worked as others reported but somehow it gave me something, I got a huge antidepressant effect that was the most free I ever felt (symptom-wise) but only for a short duration of 30-60min (really profound some antidepressant after effect). These 30-60min were worth it for me.

Then there came a time when I started Kratom again and I was suddenly getting all the effect all the Kratom fanatics described, mood lift, euphoria, energy, motivation and drive, working hard with joy and this time all this for hours instead of 30-60min only. This was the best period of kratom I had, took about 2 months. I think that‘s how it originally feels like, for most here. Never came back to this feeling. One day lost its/these effects. Well months off again.

On it again and having the subtle but antidepressant effects again. On and off.

Nowadays I get on it after maybe months off and first dose is working fine but then already the second one is already weak as hell or not noticeable at all anymore. Even when I only dose the next day. Nothing. Additionally my normal doses of 2-3g give me bad side effects now as increased (severely physical) anxiety, dizziness, nausea, lack of appetite, the wobbles etc. This happened for the last times again and again.

This last time I had a break off of Kratom for 8 days I think. Tried it again. First dose quite good. After, nothing. I tried multiple vendors, strains and batches. I even tried doses up to 10g per dose, nothing. I never did this before but I think I had a whole 30g for the whole day yesterday by experimenting if higher doses are what would work but nothing (except bigger side effects of course).

Anyone can say why the hell suddenly a body or braindecides to not be able to get effects out of the kratom leaved anymore while it used to before? I mean 10g, come on, i should definitely be feeling something and would have felt a crazy lot by that back in the days when my body was reacting to Kratom (well it still does but only side effect wise). Plus all the different vendors, strains, batches, different doses, different frequency, weeks to months t-breaks, I don‘t get why it should NOT work anymore but ONLY give bad side effects.

What could be the physiological or neuro-biochemical explanation behind this phenomenon?

As said vendor and strains are not the issue, quality is perfect, lab-proven, friends still get the best effects of the same products, other clients reporting that too, tolerance mmm Idk if even after 2-3 months nothing changes. Normally everyone even the biggest user would get something after 2-3 months off.

Can there be some neuroplastical reason or the body adapting for any reason to that the body and nervous system won‘t get any psychoactive effect from the kratom anymore (because i do get all the physical sides)? Maybe some digestion issues? Changed enzymes or changed neurological pathways?