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Half life effect on withdrawal
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Take clonazepam for example. It has half life of 60-80hrs. Duration 8-12 hours. So when you take your last dose its significiant effects on gaba A receptors will subside in 12 hours. After that it will be in system but who cares? It wont have any effect on cns. Then, why withdrawal symptoms are meant to start after 80 hours? For 68 hours, nothing will help gaba receptors but you arent going to have any withdrawal symptoms. Confused.
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