Modafinil is probably the best nootropic I have tried so far but I noticed something that is worrying. I knew that everything with such a profound effect on my memory and ability to efficiantly think must have some downsides. On off days I have severe anxiety even with some agoraphobia which I have never had before. Colors are more muted as well which reminded me of my depressive episodes. There are some studies that note modafinils serotonergic effects: "studied cortical serotonin release in vivo and vitro in rat brains. They found that modafinil is able to enhance serotonin release, but it does not cause serotonin release or reuptake on its own and suggested that modafinil increased electrosecretory coupling in neurons". Serotonin release... Can modafinil deplete serotonin as MDMA does? After mdma I noticed muted colors and severly enhanced anxiety. I can take depression but I hate anxiety. As it appears now to me I cant take modafinil. The anxiety is unbearable which again I dont feel ON modafinil but on off days. Has anybody had the same experience? I dont want to give up modafinil as it gave me a much more positive outlook on life. Everything that i thought I could not do seems possible with it. I could never focus for more than half an hour for example. I would probably do a trial of moda st. johns wort if there are no dangerous interactions, as ssris have always had a positive effect on my anxiety.