Technology is improving really quickly and so will medicine and pharmacology.

So I'm pretty sure, as drugs are slowly less and less demonized (SLOWLY) we'll get more and more compounds that are better at creating a desired effect and or much safer and forgiving.

For example scientists have found MDMA analogs that seem to not be neurotoxic like MDMA https://m.youtube.com/watch?v=dSyan8L2IJI

Imagine an MDMA analog, paired with specifically designed drugs/supplements that you can take twice a week without side effects.

Or what about cocaine that lasts hours instead of minutes and isn't cardiotoxic?

Meth that doesnt affect Hunger and sleep and isn't neurotoxic?

Probably just me wishful thinking though. I probably will die before I get my hands on any future "super drug"