So I am on fall break from studies and i just got a clonidine script and read it potentiated opiates. Also, I realized i also had hella pgp inhibitors and cyp3a4 inhibitors which would in theory just turn loperamide back into any other centrally active opioid by just allowing it to cross the BBB if i can inhibit pgp enough. I dosed like 100mg twice in 2 days. (I know about the risks and heart problems i will not do it again i just wanted to see if i could in theory get loperamide to pass the BBB and i sure did). not much euphoria but a good warmth and nice pain relief and anxiety relief. Basically felt like any opiate more respiratory depression more sedation less euphoria. Keep in mind i had to take megadoses of about 10 different supplements and other meds i had to allow it to cross. Anyways. Waking up on day 3 of the effects after I dosed the last day I was kinda tired of it and wanted to do stuff. The effects were minimal if any but i noticed some lingering opiate sedation and respiratory depression and was kinda ready for it to end, so I thought narcanning myself would do the trick and just kick out all the lope from my receptors and make me normal right??

NOOOO

15 seconds after i shot that shit in my nose i had the worst panic attack and cold knifelike pain all over my body and heart rate of 140 freaking out everything was uncomfortable sweating but cold so fucking bad oh my god i was like crying for an hour.

It went away decently fast but i developed a crippling fear of naloxone.

Safe to say I’m not ginny to fuck around with that or loperamide again i’ll just get 7-oh or something.