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Does anyone know what drugs make HRT less effective?
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I'm starting estrogen soon and I'd like to know if any of the drugs I do will make it less effective.

I currently do me kratom, let and a bit of weed. Will any of these reduce the effectiveness of hrt?

I only ask because I know nicotine does and it's important to me to know if anything else does.

I'm pretty addicted to ketamine and all but I'll stop immediately if it does actually decrease hrt effectiveness.

Any help is so so appreciated. This mattes so much to me and I want to do everything I can to make it work better.

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5 months ago